Primary Biliary Cholangitis (PBC) is a chronic, progressive autoimmune liver disease that primarily affects the bile ducts. Over time, the immune system mistakenly attacks the small bile ducts within the liver, causing inflammation and scarring (fibrosis). This damage impairs the liver’s ability to drain bile, leading to a buildup of harmful substances that can ultimately result in cirrhosis, liver failure, and the need for a transplant if left untreated. PBC predominantly affects women, with about 90% of diagnosed cases occurring in females, and its exact cause remains unclear, though genetic and environmental factors are believed to play a role. Common symptoms include fatigue, itching (pruritus), and dry eyes or mouth, while some patients may remain asymptomatic in the early stages. Although there is no cure, early diagnosis and treatment with medications like ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) can help slow disease progression and improve quality of life. Ongoing research, including patient-centered initiatives like those led by the PBC Research Foundation (PRF), is crucial to advancing treatment options and ultimately finding a cure.

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For more info visit PBCers Organization – Welcome to our community